Role of mitochondrial dysfunction in kidney disease: Insights from the cGAS-STING signaling pathway

Role of mitochondrial dysfunction in kidney disease: Insights from the cGAS-STING signaling pathway

Blog Article

Abstract.Over the past decade, mitochondrial dysfunction has been investigated as a key contributor to acute and chronic kidney disease.However, the precise molecular mechanisms linking mitochondrial damage to kidney disease remain elusive.

The recent insights into the cyclic guanosine monophosphate-adenosine monophosphate (GMP-AMP) synthetase (cGAS)-stimulator of interferon gene (STING) signaling pathway have revealed its involvement in many earthbath facial wipes renal diseases.One of these findings is that mitochondrial DNA (mtDNA) induces inflammatory responses via the cGAS-STING pathway.Herein, we provide an overview of the mechanisms underlying mtDNA release following mitochondrial damage, focusing specifically on the association between mtDNA release-activated cGAS-STING signaling and the development of kidney diseases.

Furthermore, we summarize satisfyer pro penguin next generation the latest findings of cGAS-STING signaling pathway in cell, with a particular emphasis on its downstream signaling related to kidney diseases.This review intends to enhance our understanding of the intricate relationship among the cGAS-STING pathway, kidney diseases, and mitochondrial dysfunction.